diff --git a/pkg/cmd/secret/set/set.go b/pkg/cmd/secret/set/set.go
index dade133af..9f3797008 100644
--- a/pkg/cmd/secret/set/set.go
+++ b/pkg/cmd/secret/set/set.go
@@ -4,6 +4,7 @@ import (
 	"bytes"
 	"encoding/base64"
 	"fmt"
+	"github.com/cli/cli/v2/internal/prompter"
 	"io"
 	"net/http"
 	"os"
@@ -29,7 +30,7 @@ type SetOptions struct {
 	Config     func() (gh.Config, error)
 	BaseRepo   func() (ghrepo.Interface, error)
 	Remotes    func() (ghContext.Remotes, error)
-	Prompter   iprompter
+	Prompter   prompter.Prompter
 
 	RandomOverride func() io.Reader
 
@@ -45,10 +46,7 @@ type SetOptions struct {
 	Application     string
 
 	HasRepoOverride bool
-}
-
-type iprompter interface {
-	Password(string) (string, error)
+	Interactive     bool
 }
 
 func NewCmdSet(f *cmdutil.Factory, runF func(*SetOptions) error) *cobra.Command {
@@ -82,6 +80,9 @@ func NewCmdSet(f *cmdutil.Factory, runF func(*SetOptions) error) *cobra.Command
 			# Read secret value from an environment variable
 			$ gh secret set MYSECRET --body "$ENV_VALUE"
 
+			# Set secret for a specific remote repository
+			$ gh secret set MYSECRET --repo origin/repo --body "$ENV_VALUE"
+
 			# Read secret value from a file
 			$ gh secret set MYSECRET < myfile.txt
 
@@ -111,6 +112,8 @@ func NewCmdSet(f *cmdutil.Factory, runF func(*SetOptions) error) *cobra.Command
 			// support `-R, --repo` override
 			opts.BaseRepo = f.BaseRepo
 
+			flagCount := cmdutil.CountSetFlags(cmd.Flags())
+
 			if err := cmdutil.MutuallyExclusive("specify only one of `--org`, `--env`, or `--user`", opts.OrgName != "", opts.EnvName != "", opts.UserSecrets); err != nil {
 				return err
 			}
@@ -129,6 +132,10 @@ func NewCmdSet(f *cmdutil.Factory, runF func(*SetOptions) error) *cobra.Command
 				}
 			} else {
 				opts.SecretName = args[0]
+
+				if flagCount == 0 {
+					opts.Interactive = true
+				}
 			}
 
 			if cmd.Flags().Changed("visibility") {
@@ -197,7 +204,17 @@ func setRun(opts *SetOptions) error {
 
 		err = cmdutil.ValidateHasOnlyOneRemote(opts.HasRepoOverride, opts.Remotes)
 		if err != nil {
-			return err
+			if opts.Interactive {
+				selectedRepo, errSelectedRepo := cmdutil.PromptForRepo(baseRepo, opts.Remotes, opts.Prompter)
+
+				if errSelectedRepo != nil {
+					return errSelectedRepo
+				}
+
+				baseRepo = selectedRepo
+			} else {
+				return err
+			}
 		}
 
 		host = baseRepo.RepoHost()
diff --git a/pkg/cmdutil/flags.go b/pkg/cmdutil/flags.go
index c0064099c..fadbc5fbe 100644
--- a/pkg/cmdutil/flags.go
+++ b/pkg/cmdutil/flags.go
@@ -180,3 +180,11 @@ func isIncluded(value string, opts []string) bool {
 	}
 	return false
 }
+
+func CountSetFlags(flags *pflag.FlagSet) int {
+	count := 0
+	flags.Visit(func(f *pflag.Flag) {
+		count++
+	})
+	return count
+}
diff --git a/pkg/cmdutil/repo_override.go b/pkg/cmdutil/repo_override.go
index 791dd919a..41a4a4799 100644
--- a/pkg/cmdutil/repo_override.go
+++ b/pkg/cmdutil/repo_override.go
@@ -1,11 +1,13 @@
 package cmdutil
 
 import (
+	ghContext "github.com/cli/cli/v2/context"
 	"os"
 	"sort"
 	"strings"
 
 	"github.com/cli/cli/v2/internal/ghrepo"
+	"github.com/cli/cli/v2/internal/prompter"
 	"github.com/spf13/cobra"
 )
 
@@ -68,3 +70,34 @@ func OverrideBaseRepoFunc(f *Factory, override string) func() (ghrepo.Interface,
 	}
 	return f.BaseRepo
 }
+
+func PromptForRepo(baseRepo ghrepo.Interface, remotes func() (ghContext.Remotes, error), survey prompter.Prompter) (ghrepo.Interface, error) {
+	var defaultRepo string
+	var remoteArray []string
+
+	if remotes, _ := remotes(); remotes != nil {
+		if defaultRemote, _ := remotes.ResolvedRemote(); defaultRemote != nil {
+			// this is a remote explicitly chosen via `repo set-default`
+			defaultRepo = ghrepo.FullName(defaultRemote)
+		} else if len(remotes) > 0 {
+			// as a fallback, just pick the first remote
+			defaultRepo = ghrepo.FullName(remotes[0])
+		}
+
+		for _, remote := range remotes {
+			remoteArray = append(remoteArray, ghrepo.FullName(remote))
+		}
+	}
+
+	baseRepoInput, errInput := survey.Select("Select a base repo", defaultRepo, remoteArray)
+	if errInput != nil {
+		return baseRepo, errInput
+	}
+
+	selectedRepo, errSelectedRepo := ghrepo.FromFullName(remoteArray[baseRepoInput])
+	if errSelectedRepo != nil {
+		return baseRepo, errSelectedRepo
+	}
+
+	return selectedRepo, nil
+}