diff --git a/pkg/cmd/issue/edit/edit.go b/pkg/cmd/issue/edit/edit.go
index 1b775f88b..11a69383d 100644
--- a/pkg/cmd/issue/edit/edit.go
+++ b/pkg/cmd/issue/edit/edit.go
@@ -46,6 +46,7 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 	}
 
 	var bodyFile string
+	var removeMilestone bool
 
 	cmd := &cobra.Command{
 		Use:   "edit {<numbers> | <urls>}",
@@ -62,6 +63,7 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 			$ gh issue edit 23 --add-assignee "@me" --remove-assignee monalisa,hubot
 			$ gh issue edit 23 --add-project "Roadmap" --remove-project v1,v2
 			$ gh issue edit 23 --milestone "Version 1"
+			$ gh issue edit 23 --remove-milestone
 			$ gh issue edit 23 --body-file body.txt
 			$ gh issue edit 23 34 --add-label "help wanted"
 		`),
@@ -95,6 +97,14 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 				}
 			}
 
+			if err := cmdutil.MutuallyExclusive(
+				"specify only one of `--milestone` or `--remove-milestone`",
+				flags.Changed("milestone"),
+				removeMilestone,
+			); err != nil {
+				return err
+			}
+
 			if flags.Changed("title") {
 				opts.Editable.Title.Edited = true
 			}
@@ -107,8 +117,13 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 			if flags.Changed("add-project") || flags.Changed("remove-project") {
 				opts.Editable.Projects.Edited = true
 			}
-			if flags.Changed("milestone") {
+			if flags.Changed("milestone") || removeMilestone {
 				opts.Editable.Milestone.Edited = true
+
+				// Note that when `--remove-milestone` is provided, the value of
+				// `opts.Editable.Milestone.Value` will automatically be empty,
+				// which results in milestone association removal. For reference,
+				// see the `Editable.MilestoneId` method.
 			}
 
 			if !opts.Editable.Dirty() {
@@ -141,6 +156,7 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 	cmd.Flags().StringSliceVar(&opts.Editable.Projects.Add, "add-project", nil, "Add the issue to projects by `name`")
 	cmd.Flags().StringSliceVar(&opts.Editable.Projects.Remove, "remove-project", nil, "Remove the issue from projects by `name`")
 	cmd.Flags().StringVarP(&opts.Editable.Milestone.Value, "milestone", "m", "", "Edit the milestone the issue belongs to by `name`")
+	cmd.Flags().BoolVar(&removeMilestone, "remove-milestone", false, "Remove the milestone association from the issue")
 
 	return cmd
 }
diff --git a/pkg/cmd/issue/edit/edit_test.go b/pkg/cmd/issue/edit/edit_test.go
index db0b09d2d..40fe6491c 100644
--- a/pkg/cmd/issue/edit/edit_test.go
+++ b/pkg/cmd/issue/edit/edit_test.go
@@ -104,6 +104,11 @@ func TestNewCmdEdit(t *testing.T) {
 			},
 			wantsErr: false,
 		},
+		{
+			name:     "both body and body-file flags",
+			input:    "23 --body foo --body-file bar",
+			wantsErr: true,
+		},
 		{
 			name:  "add-assignee flag",
 			input: "23 --add-assignee monalisa,hubot",
@@ -206,6 +211,25 @@ func TestNewCmdEdit(t *testing.T) {
 			},
 			wantsErr: false,
 		},
+		{
+			name:  "remove-milestone flag",
+			input: "23 --remove-milestone",
+			output: EditOptions{
+				SelectorArgs: []string{"23"},
+				Editable: prShared.Editable{
+					Milestone: prShared.EditableString{
+						Value:  "",
+						Edited: true,
+					},
+				},
+			},
+			wantsErr: false,
+		},
+		{
+			name:     "both milestone and remove-milestone flags",
+			input:    "23 --milestone foo --remove-milestone",
+			wantsErr: true,
+		},
 		{
 			name:  "add label to multiple issues",
 			input: "23 34 --add-label bug",
@@ -221,17 +245,8 @@ func TestNewCmdEdit(t *testing.T) {
 			wantsErr: false,
 		},
 		{
-			name:  "interactive multiple issues",
-			input: "23 34",
-			output: EditOptions{
-				SelectorArgs: []string{"23", "34"},
-				Editable: prShared.Editable{
-					Labels: prShared.EditableSlice{
-						Add:    []string{"bug"},
-						Edited: true,
-					},
-				},
-			},
+			name:     "interactive multiple issues",
+			input:    "23 34",
 			wantsErr: true,
 		},
 	}
diff --git a/pkg/cmd/pr/edit/edit.go b/pkg/cmd/pr/edit/edit.go
index 3f80aa80a..9dc190011 100644
--- a/pkg/cmd/pr/edit/edit.go
+++ b/pkg/cmd/pr/edit/edit.go
@@ -43,6 +43,7 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 	}
 
 	var bodyFile string
+	var removeMilestone bool
 
 	cmd := &cobra.Command{
 		Use:   "edit [<number> | <url> | <branch>]",
@@ -63,6 +64,7 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 			$ gh pr edit 23 --add-assignee "@me" --remove-assignee monalisa,hubot
 			$ gh pr edit 23 --add-project "Roadmap" --remove-project v1,v2
 			$ gh pr edit 23 --milestone "Version 1"
+			$ gh pr edit 23 --remove-milestone
 		`),
 		Args: cobra.MaximumNArgs(1),
 		RunE: func(cmd *cobra.Command, args []string) error {
@@ -95,6 +97,14 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 				}
 			}
 
+			if err := cmdutil.MutuallyExclusive(
+				"specify only one of `--milestone` or `--remove-milestone`",
+				flags.Changed("milestone"),
+				removeMilestone,
+			); err != nil {
+				return err
+			}
+
 			if flags.Changed("title") {
 				opts.Editable.Title.Edited = true
 			}
@@ -116,8 +126,13 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 			if flags.Changed("add-project") || flags.Changed("remove-project") {
 				opts.Editable.Projects.Edited = true
 			}
-			if flags.Changed("milestone") {
+			if flags.Changed("milestone") || removeMilestone {
 				opts.Editable.Milestone.Edited = true
+
+				// Note that when `--remove-milestone` is provided, the value of
+				// `opts.Editable.Milestone.Value` will automatically be empty,
+				// which results in milestone association removal. For reference,
+				// see the `Editable.MilestoneId` method.
 			}
 
 			if !opts.Editable.Dirty() {
@@ -149,6 +164,7 @@ func NewCmdEdit(f *cmdutil.Factory, runF func(*EditOptions) error) *cobra.Comman
 	cmd.Flags().StringSliceVar(&opts.Editable.Projects.Add, "add-project", nil, "Add the pull request to projects by `name`")
 	cmd.Flags().StringSliceVar(&opts.Editable.Projects.Remove, "remove-project", nil, "Remove the pull request from projects by `name`")
 	cmd.Flags().StringVarP(&opts.Editable.Milestone.Value, "milestone", "m", "", "Edit the milestone the pull request belongs to by `name`")
+	cmd.Flags().BoolVar(&removeMilestone, "remove-milestone", false, "Remove the milestone association from the pull request")
 
 	_ = cmdutil.RegisterBranchCompletionFlags(f.GitClient, cmd, "base")
 
diff --git a/pkg/cmd/pr/edit/edit_test.go b/pkg/cmd/pr/edit/edit_test.go
index 0986797ea..3c4882961 100644
--- a/pkg/cmd/pr/edit/edit_test.go
+++ b/pkg/cmd/pr/edit/edit_test.go
@@ -112,6 +112,11 @@ func TestNewCmdEdit(t *testing.T) {
 			},
 			wantsErr: false,
 		},
+		{
+			name:     "both body and body-file flags",
+			input:    "23 --body foo --body-file bar",
+			wantsErr: true,
+		},
 		{
 			name:  "base flag",
 			input: "23 --base base-branch-name",
@@ -256,6 +261,25 @@ func TestNewCmdEdit(t *testing.T) {
 			},
 			wantsErr: false,
 		},
+		{
+			name:  "remove-milestone flag",
+			input: "23 --remove-milestone",
+			output: EditOptions{
+				SelectorArg: "23",
+				Editable: shared.Editable{
+					Milestone: shared.EditableString{
+						Value:  "",
+						Edited: true,
+					},
+				},
+			},
+			wantsErr: false,
+		},
+		{
+			name:     "both milestone and remove-milestone flags",
+			input:    "23 --milestone foo --remove-milestone",
+			wantsErr: true,
+		},
 	}
 	for _, tt := range tests {
 		t.Run(tt.name, func(t *testing.T) {