diff --git a/api/queries_pr.go b/api/queries_pr.go
index de98c661f..d994d3aae 100644
--- a/api/queries_pr.go
+++ b/api/queries_pr.go
@@ -701,6 +701,114 @@ func RemovePullRequestReviews(client *Client, repo ghrepo.Interface, prNumber in
 	return client.REST(repo.RepoHost(), "DELETE", path, buf, nil)
 }
 
+// SuggestedAssignableActors fetches up to 10 suggested actors for a specific assignable
+// (Issue or PullRequest) node ID. `assignableID` is the GraphQL node ID for the Issue/PR.
+// If query is empty, the query variable is passed as null to omit filtering.
+func SuggestedAssignableActors(client *Client, repo ghrepo.Interface, assignableID string, query string) ([]AssignableActor, error) {
+	type responseData struct {
+		Viewer struct {
+			ID    string
+			Login string
+			Name  string
+		} `graphql:"viewer"`
+		Node struct {
+			Issue struct {
+				SuggestedActors struct {
+					Nodes []struct {
+						User struct {
+							ID       string
+							Login    string
+							Name     string
+							TypeName string `graphql:"__typename"`
+						} `graphql:"... on User"`
+						Bot struct {
+							ID       string
+							Login    string
+							TypeName string `graphql:"__typename"`
+						} `graphql:"... on Bot"`
+					}
+				} `graphql:"suggestedActors(first: 10, query: $query)"`
+			} `graphql:"... on Issue"`
+			PullRequest struct {
+				SuggestedActors struct {
+					Nodes []struct {
+						User struct {
+							ID       string
+							Login    string
+							Name     string
+							TypeName string `graphql:"__typename"`
+						} `graphql:"... on User"`
+						Bot struct {
+							ID       string
+							Login    string
+							TypeName string `graphql:"__typename"`
+						} `graphql:"... on Bot"`
+					}
+				} `graphql:"suggestedActors(first: 10, query: $query)"`
+			} `graphql:"... on PullRequest"`
+		} `graphql:"node(id: $id)"`
+	}
+
+	variables := map[string]interface{}{
+		"id": githubv4.ID(assignableID),
+	}
+	if query != "" {
+		variables["query"] = githubv4.String(query)
+	} else {
+		variables["query"] = (*githubv4.String)(nil)
+	}
+
+	var result responseData
+	if err := client.Query(repo.RepoHost(), "SuggestedAssignableActors", &result, variables); err != nil {
+		return nil, err
+	}
+
+	var nodes []struct {
+		User struct {
+			ID       string
+			Login    string
+			Name     string
+			TypeName string `graphql:"__typename"`
+		} `graphql:"... on User"`
+		Bot struct {
+			ID       string
+			Login    string
+			TypeName string `graphql:"__typename"`
+		} `graphql:"... on Bot"`
+	}
+
+	if result.Node.PullRequest.SuggestedActors.Nodes != nil {
+		nodes = result.Node.PullRequest.SuggestedActors.Nodes
+	} else if result.Node.Issue.SuggestedActors.Nodes != nil {
+		nodes = result.Node.Issue.SuggestedActors.Nodes
+	}
+
+	actors := make([]AssignableActor, 0, len(nodes)+1) // +1 in case we add viewer
+	viewer := result.Viewer
+	viewerLogin := viewer.Login
+	viewerIncluded := false
+
+	for _, n := range nodes {
+		if n.User.TypeName == "User" && n.User.Login != "" {
+			actors = append(actors, AssignableUser{id: n.User.ID, login: n.User.Login, name: n.User.Name})
+			if query == "" && viewerLogin != "" && n.User.Login == viewerLogin {
+				viewerIncluded = true
+			}
+		} else if n.Bot.TypeName == "Bot" && n.Bot.Login != "" {
+			actors = append(actors, AssignableBot{id: n.Bot.ID, login: n.Bot.Login})
+			if query == "" && viewerLogin != "" && n.Bot.Login == viewerLogin {
+				viewerIncluded = true
+			}
+		}
+	}
+
+	// When query is blank, append viewer if not already present.
+	if query == "" && viewerLogin != "" && !viewerIncluded {
+		actors = append(actors, AssignableUser{id: viewer.ID, login: viewer.Login, name: viewer.Name})
+	}
+	return actors, nil
+}
+
 func UpdatePullRequestBranch(client *Client, repo ghrepo.Interface, params githubv4.UpdatePullRequestBranchInput) error {
 	var mutation struct {
 		UpdatePullRequestBranch struct {
diff --git a/pkg/cmd/pr/edit/edit.go b/pkg/cmd/pr/edit/edit.go
index 11cb74b1f..f62ca096b 100644
--- a/pkg/cmd/pr/edit/edit.go
+++ b/pkg/cmd/pr/edit/edit.go
@@ -292,6 +292,10 @@ func editRun(opts *EditOptions) error {
 
 	apiClient := api.NewClientFromHTTP(httpClient)
 
+	// Wire up search functions for assignees and reviewers.
+	// TODO: Wire up reviewer search func.
+	editable.AssigneeSearchFunc = assigneeSearchFunc(apiClient, repo, pr.ID)
+
 	opts.IO.StartProgressIndicator()
 	err = opts.Fetcher.EditableOptionsFetch(apiClient, repo, &editable, opts.Detector.ProjectsV1())
 	opts.IO.StopProgressIndicator()
@@ -331,6 +335,38 @@ func editRun(opts *EditOptions) error {
 	return nil
 }
 
+func assigneeSearchFunc(apiClient *api.Client, repo ghrepo.Interface, assignableID string) func(string) ([]string, []string, int, error) {
+	searchFunc := func(input string) ([]string, []string, int, error) {
+		actors, err := api.SuggestedAssignableActors(
+			apiClient,
+			repo,
+			assignableID,
+			input)
+		if err != nil {
+			return nil, nil, 0, err
+		}
+
+		var logins []string
+		var displayNames []string
+
+		for _, a := range actors {
+			if a.Login() != "" {
+				logins = append(logins, a.Login())
+			} else {
+				continue
+			}
+
+			if a.DisplayName() != "" {
+				displayNames = append(displayNames, a.DisplayName())
+			} else {
+				displayNames = append(displayNames, a.Login())
+			}
+		}
+		return logins, displayNames, 0, nil
+	}
+	return searchFunc
+}
+
 func updatePullRequest(httpClient *http.Client, repo ghrepo.Interface, id string, number int, editable shared.Editable) error {
 	var wg errgroup.Group
 	wg.Go(func() error {
diff --git a/pkg/cmd/pr/shared/editable.go b/pkg/cmd/pr/shared/editable.go
index 5cf55ad37..c69e5a0b5 100644
--- a/pkg/cmd/pr/shared/editable.go
+++ b/pkg/cmd/pr/shared/editable.go
@@ -10,15 +10,17 @@ import (
 )
 
 type Editable struct {
-	Title     EditableString
-	Body      EditableString
-	Base      EditableString
-	Reviewers EditableSlice
-	Assignees EditableAssignees
-	Labels    EditableSlice
-	Projects  EditableProjects
-	Milestone EditableString
-	Metadata  api.RepoMetadataResult
+	Title              EditableString
+	Body               EditableString
+	Base               EditableString
+	Reviewers          EditableSlice
+	ReviewerSearchFunc func(string) ([]string, []string, error)
+	Assignees          EditableAssignees
+	AssigneeSearchFunc func(string) ([]string, []string, int, error)
+	Labels             EditableSlice
+	Projects           EditableProjects
+	Milestone          EditableString
+	Metadata           api.RepoMetadataResult
 }
 
 type EditableString struct {
@@ -277,6 +279,7 @@ type EditPrompter interface {
 	Input(string, string) (string, error)
 	MarkdownEditor(string, string, bool) (string, error)
 	MultiSelect(string, []string, []string) ([]int, error)
+	MultiSelectWithSearch(prompt, searchPrompt string, defaults []string, persistentOptions []string, searchFunc func(string) ([]string, []string, int, error)) ([]string, error)
 	Confirm(string, bool) (bool, error)
 }
 
@@ -302,10 +305,24 @@ func EditFieldsSurvey(p EditPrompter, editable *Editable, editorCommand string)
 		}
 	}
 	if editable.Assignees.Edited {
-		editable.Assignees.Value, err = multiSelectSurvey(
-			p, "Assignees", editable.Assignees.Default, editable.Assignees.Options)
-		if err != nil {
-			return err
+		if editable.AssigneeSearchFunc != nil {
+			editable.Assignees.Options = []string{}
+			editable.Assignees.Value, err = p.MultiSelectWithSearch(
+				"Assignees",
+				"Search assignees",
+				editable.Assignees.DefaultLogins,
+				// No persistent options required here as teams cannot be assignees.
+				[]string{},
+				editable.AssigneeSearchFunc)
+			if err != nil {
+				return err
+			}
+		} else {
+			editable.Assignees.Value, err = multiSelectSurvey(
+				p, "Assignees", editable.Assignees.Default, editable.Assignees.Options)
+			if err != nil {
+				return err
+			}
 		}
 	}
 	if editable.Labels.Edited {
@@ -408,10 +425,21 @@ func FetchOptions(client *api.Client, repo ghrepo.Interface, editable *Editable,
 			teamReviewers = true
 		}
 	}
+
+	fetchAssignees := false
+	if editable.Assignees.Edited {
+		// Similar as above, this is likely an interactive flow if no Add/Remove slices are set.
+		// The addition here is that we also check for an assignee search func because
+		// if that is set, the prompter will handle dynamic fetching of assignees.
+		if len(editable.Assignees.Add) == 0 && len(editable.Assignees.Remove) == 0 && editable.AssigneeSearchFunc == nil {
+			fetchAssignees = true
+		}
+	}
+
 	input := api.RepoMetadataInput{
 		Reviewers:      editable.Reviewers.Edited,
 		TeamReviewers:  teamReviewers,
-		Assignees:      editable.Assignees.Edited,
+		Assignees:      fetchAssignees,
 		ActorAssignees: editable.Assignees.ActorAssignees,
 		Labels:         editable.Labels.Edited,
 		ProjectsV1:     editable.Projects.Edited && projectV1Support == gh.ProjectsV1Supported,